The Effect of Alcohol Consumption on the Urinary Testosterone / Epitestosterone Ratio
By Dr Simon Davis B.Sc., Ph.D.
Summary
Intoxicating beverages contain a number of different forms of alcohol, the major constituent of which is ethanol. When a beverage is consumed the ethanol content passes through the stomach wall and digestive tract into the blood stream. Once the ethanol enters circulation it begins to alter the bodies' biochemistry. One such reaction is to differentially increase the rates of testosterone (T) and epitestosterone (E) metabolism. The overall effect of this reaction is to increase the ratio of T to E excreted in the urine.
It has been reported that ethanol consumption can increase urinary T/E ratios by 30% - 277% in healthy individuals. Observed changes in plasma T/E ratios can occur with the consumption of less than 2 pints of lager. The ingestion of ethanol by an individual will increase the T/E ratio observed in a urine sample.
It follows that if the effect of ethanol on T/E ratios is calculated relative to urinary E concentrations, it can be seen that increases in the ratio are exponential as E concentrations decrease. Individuals with naturally low E concentrations could, therefore, experience increases in T/E ratios of ? 940% greater than increases experienced in an individual with normal E concentrations. Calculations estimate that in individuals with low urinary E concentration, ratios of 17 to 1 or higher could have resulted from ethanol consumption without any administration of exogenous T.
The current T/E ratio test as performed by Kings College Laboratory and approved by the UK Sports, the IWF and IOC cannot discriminate between a 13 to 1 T/E ratio resulting from ethanol ingestion or a 13 to 1 ratio resulting from endogenous T administration.
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3 comments:
The pessimist in me says:
So Dr. Allen Lim, Floyd's trainer injects him with testosterone the night before stage 17. He gives him a measured dose, enough to have an effect yet not too much to blow the lid off the tests. Knowing that if Floyd wins his blood will not be sampled but rather his urine he sees a chance to manipulate the sample. He tells Floyd that it's imperative that he down as much water as possible in an effort to flush his system clean- potheads do a similar process to clean their urine before a drug test, and while not always foolproof, the thinning of the urine does minimize the chance of anything showing up in anything above a negligible amount. Floyd wins and as a result pees into the cup.
The optimist in me thinks:
The beer excuse
or
Ain't it possible that Floyd psyched himself up so much, was so angry, was so "Alpha" that his brain went and jacked up the "man juice" production...
I think the general public definately finds a man dressed like a leprechaun rocking a porn-star 'stash much more trustworthy.
Thanks for this Steve. Time will tell. I, for one, didn't give a shit about Tyler but will dissapointed if Floyd really is juiced.
motherfucker!
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